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ErbB3信息

英文名称:Receptor tyrosine-protein kinase erbB-3
中文名称:受体酪氨酸蛋白激酶erbB-3
靶点别称:ERBB3,Receptor tyrosine-protein kinase erbB-3,HER3,Tyrosine kinase-type cell surface receptor HER3,Proto-oncogene-like protein c-ErbB-3
上市药物数量:0
临床药物数量:26
最高研发阶段:临床三期

ErbB3 Molecule Synonym Name

ERBB3,HER3,LCCS2,MDA-BF-1,MGC88033,c-erbB3,erbB3-S,p180-ErbB3,p45-sErbB3,p85-sErbB3

ErbB3 分子背景

ErbB3,also known as Her3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain. It therefore can bind the ligand but cannot mediate the intracellular signal transduction through protein phosphorylation. However, it does form heterodimers with ErbB2 or other EGFR members responsible for tyrosine phosphorylation to give a receptor complex and initiate the related pathway, which lead to cell proliferation or differentiation. Overexpression of this protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.

ErbB3 参考文献

ErbB3临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
KTN-3379 KTN-3379; CDX-3379,KTN3379; CDX3379 临床二期 MedImmune, Kolltan 甲状腺癌, 实体瘤, 头颈癌 详情
Allitinib Tosylate AST-6; ALS-1306; AST-1306 临床二期 上海艾力斯 乳腺癌, 肺癌
AC-480 AC-480; BMS-599626 ,AC480; BMS599626 ,AC 480; BMS 599626 临床一期 Ambit biosciences 神经胶质瘤, 实体瘤 详情
Patritumab AMG-888; U3-1287,AMG888,U31287 临床三期 第一三共, 安进 非小细胞肺癌, 转移性乳腺癌 详情
SPC-3920 SPC-3920; EZN-3920 临床前 罗氏 癌症
Seribantumab MM-121; SAR-256212; 1N3L70MDFX (UNII code) 临床二期 Merrimack, 赛诺菲 非小细胞肺癌, 乳腺癌, 实体瘤, 卵巢癌 详情
Sapitinib AZD-8931 临床二期 阿斯利康 结肠直肠癌 详情
ISU-104 ISU-104 临床一期 ISU Abxis 实体瘤 详情
REGN-1400 REGN-1400 临床一期 再生元制药 实体瘤 详情
GSK-2849330 GSK-2849330,GSK2849330 临床一期 葛兰素史克 实体瘤 详情
Recombinant human ErbB3 fragment vaccine (Zensun) rhErbB3-f 临床一期 上海泽生科技 实体瘤
Tesevatinib EXEL-7647; KD-019; KD-020; XL-647,KD019,EXEL7647,KD020,XL647 临床三期 Exelixis, Kadmon 非小细胞肺癌, 常染色体显性多囊肾病 详情
MP-0274 CME-114; SPA-28; MP-0274; CME-119; CME-118; CME-115; DARPin-41 临床一期 Molecular Partners 实体瘤 详情
Elisidepsin PM-02734; PM-2734 临床二期 PharmaMar 实体瘤 详情
Recombinat humanized HER3-targeting antibody 临床一期 上海生物制品研究所 实体瘤
Sirotinib Maleate XZP-5491,XZP5491 临床一期 轩竹医药 食管鳞癌, 非小细胞肺癌, 胃癌
Sym-013 Sym-013,Sym 013,Sym013 临床二期 Symphogen 癌症 详情
U3-1402 U3-1402,U31402; U3 1402 临床二期 第一三共 非小细胞肺癌, 乳腺癌 详情
Duligotuzumab (Genentech) MEHD-7945A; RG-7597; RO-5541078,MEHD7945A; RG7597; RO5541078 临床一期 基因泰克 实体瘤 详情
MM-111 MM-111 临床二期 Merrimack 胃癌, 食道癌, 乳腺癌, 实体瘤 详情
Zenocutuzumab MCLA-128 临床二期 Merus 非小细胞肺癌, 胃癌, 实体瘤, 转移性乳腺癌, 卵巢癌 详情
Lumretuzumab RG-7116; RO-5479599 临床二期 罗氏 非小细胞肺癌, 乳腺癌, 实体瘤 详情
Elgemtumab LJM-716; NOV-6 临床二期 MorphoSys, 诺华 胃癌, 食道癌, 乳腺癌, 实体瘤, 头颈癌 详情
TAD011 TAD-011,TAD011; TAD 011 临床申请 东曜药业 脑肿瘤, 结肠直肠癌, 头颈癌, 胰腺癌
AV-203 AV-203; CAN-017,CAN017 临床一期 AVEO, 北海康成 实体瘤 详情
Istiratumab MM-141; XLR461MD3M (UNII code) 临床二期 Merrimack, Shire, Adimab 卵巢癌, 胰腺癌 详情

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