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EpCAM信息

英文名称:Epithelial cell adhesion molecule
中文名称:上皮细胞粘附分子
靶点别称:MIC18,EPCAM,GA733-2 ,Epithelial cell adhesion molecule,EGP,Epithelial cell surface antigen,TACSTD1,hEGP314,KS 1/4 antigen,M1S2,TROP1,Major gastrointestinal tumor-associated protein GA733-2,Epithelial glycoprotein 314,EGP314,M4S1,Cell surface glycoprotein
上市药物数量:1
临床药物数量:24
最高研发阶段:批准上市

EpCAM 分子别名

EPCAM,TACSTD1,TROP1,CD326,DIAR5,EGP2,EGP314,EGP40,ESA,GA733-2,HNPCC8,HNPCC-8,KS1/4,KSA,M4S1,MIC18,MK1

EpCAM 分子背景

EpCAM is also known as CO171A, EGP, EGP40,GA7332, KSA, M4S, MIC18, MK1, TROP1, hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A(mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy. Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer.

EpCAM 参考文献

EpCAM上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Catumaxomab 批准上市 Trion Research, Neovii Biotech catumaxomab ema

Removab is indicated for the intraperitoneal treatment of malignant ascites in patients with EpCAM-positive carcinomas where standard therapy is not available or no longer feasible.

Neovii Biotech GmbH 2009-04-20 恶性腹腔积液 详情

EpCAM临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
VB1-050 (Sesen Bio) VBX-050; VB1-050,VBX 050; VB1 050,VBX050; VB1050 临床前 Sesen Bio 结肠癌, 胃癌, 前列腺癌, 肝癌
Anti-EPCAM CAR-T cell therapy (Sinobioway) 临床二期 北大未名细胞治疗中心 胃癌, 肝癌
M-701 M-701 临床一期 武汉友芝友生物 恶性腹腔积液
Anti-17-1A monoclonal antibody 3622W94 临床二期 葛兰素史克 非小细胞肺癌, 前列腺癌
ING-1 ING-1 临床一期 Xoma, Aduro BioTech 腺癌 详情
Citatuzumab bogatox VB6-845; VB6-845d 临床一期 Viventia Biotech, Sesen Bio 实体瘤 详情
Anti-KSA cancer vaccine (IDM Pharma) 临床一期 IDM Pharma, Walter Reed Army Institute of Research 前列腺癌, 结肠直肠癌
A-337 A-337 临床一期 健能隆医药 实体瘤
VB-4011 (Sesen Bio) VB-4011 临床前 Viventia Biotech, Sesen Bio 癌症
VB1-008 (Sesen Bio) VB1-008; VBX-008,VB1 008; VBX 008,VB1008; VBX008 临床前 Sesen Bio 癌症
Anti-CD3/MUC-1/CEA/EpCAM/GPC-3 (Benhealth Biopharmaceutical) 临床二期 本康生物 肝癌 详情
NP-1 (Sesen Bio) NP-1,NP 1,NP1 临床前 Sesen Bio 癌症
Oportuzumab monatox 4D5MOCB-ETA; VB4-845; VB-4847; VB-845,B4845 临床三期 Viventia Biotech, Sesen Bio 膀胱癌 详情
Monoclonal antibody BIS-1 临床一期 格罗宁根大学医院 恶性胸腔积液, 肾癌, 恶性腹腔积液
VB-6901 (Sesen Bio) VB-6901 临床前 Viventia Biotech, Sesen Bio 癌症
186Re-NR-LU-10 186Re-NR-LU-10; NR-LU-10-186Re 临床一期 Poniard Pharmaceuticals 实体瘤
Anti-EpCAM cancer vaccine (Aphton) IGN-101 临床三期 Aphton Corporation, Altropus 非小细胞肺癌
Staphylococcus aureus immune globulin (Inhibitex) SA-IGIV; INH-A21; INH-A00021,SA IGIV; INH A21; INH A00021 临床三期 百时美施贵宝 葡萄球菌感染
AT-003 AT-003 临床前 Affitech 癌症
VB-6050 (Sesen Bio) VB-6050 临床前 Viventia Biotech, Sesen Bio 癌症
Monoclonal antibody 323A3 临床一期 Centocor, Nonindustrial source 乳腺癌, 癌症
Edrecolomab 撤市 强生, 葛兰素史克, 味之素 结肠直肠癌 详情
Solitumomab AMG-110; MT-110 临床一期 Micromet 实体瘤 详情
Adecatumumab MT-201,MT201 临床二期 安进, 默克雪兰诺 前列腺癌, 乳腺癌, 结肠直肠癌 详情

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