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EpCAM信息

英文名称:Epithelial cell adhesion molecule
中文名称:上皮细胞粘附分子
靶点别称:MIC18,EPCAM,GA733-2 ,Epithelial cell adhesion molecule,EGP,Epithelial cell surface antigen,TACSTD1,hEGP314,KS 1/4 antigen,M1S2,TROP1,Major gastrointestinal tumor-associated protein GA733-2,Epithelial glycoprotein 314,EGP314,M4S1,Cell surface glycoprotein
上市药物数量:0
临床药物数量:23
最高研发阶段:撤市

EpCAM Molecule Synonym Name

EPCAM,TACSTD1,TROP1,CD326,DIAR5,EGP2,EGP314,EGP40,ESA,GA733-2,HNPCC8,HNPCC-8,KS1/4,KSA,M4S1,MIC18,MK1

EpCAM 分子背景

EpCAM is also known as CO171A, EGP, EGP40,GA7332, KSA, M4S, MIC18, MK1, TROP1, hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A(mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy. Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer.

EpCAM 参考文献

EpCAM临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
VB1-050 (Sesen Bio) VBX-050; VB1-050,VBX 050; VB1 050,VBX050; VB1050 临床前 Sesen Bio 结肠癌, 胃癌, 前列腺癌, 肝癌
Anti-EPCAM CAR-T cell therapy (Sinobioway) 临床二期 北大未名细胞治疗中心 胃癌, 肝癌
M-701 M-701 临床一期 武汉友芝友生物 恶性腹腔积液
Anti-17-1A monoclonal antibody 3622W94 临床二期 葛兰素史克 非小细胞肺癌, 前列腺癌
ING-1 ING-1 临床一期 Xoma, Aduro BioTech 腺癌 详情
Citatuzumab bogatox VB6-845; VB6-845d 临床一期 Viventia Biotech, Sesen Bio 实体瘤 详情
Anti-KSA cancer vaccine (IDM Pharma) 临床一期 IDM Pharma, Walter Reed Army Institute of Research 前列腺癌, 结肠直肠癌
A-337 A-337 临床一期 健能隆医药 实体瘤
VB-4011 (Sesen Bio) VB-4011 临床前 Viventia Biotech, Sesen Bio 癌症
VB1-008 (Sesen Bio) VB1-008; VBX-008,VB1 008; VBX 008,VB1008; VBX008 临床前 Sesen Bio 癌症
NP-1 (Sesen Bio) NP-1 (Sesen Bio),NP 1 (Sesen Bio),NP1 (Sesen Bio) 临床前 Sesen Bio 癌症
Oportuzumab monatox 4D5MOCB-ETA; VB4-845; VB-4847; VB-845; B-4845 BLA 申请 Viventia Biotech, Sesen Bio 膀胱癌 详情
Monoclonal antibody BIS-1 临床一期 格罗宁根大学医院 恶性胸腔积液, 肾癌, 恶性腹腔积液
VB-6901 (Sesen Bio) VB-6901 临床前 Viventia Biotech, Sesen Bio 癌症
186Re-NR-LU-10 186Re-NR-LU-10; NR-LU-10-186Re 临床一期 Poniard Pharmaceuticals 实体瘤
Anti-EpCAM cancer vaccine (Aphton) IGN-101 临床三期 Aphton Corporation, Altropus 非小细胞肺癌
Catumaxomab LP000 撤市 Trion Research, Neovii Biotech, 凌腾医药 恶性腹腔积液 详情
AT-003 AT-003 临床前 Affitech 癌症
VB-6050 (Sesen Bio) VB-6050 临床前 Viventia Biotech, Sesen Bio 癌症
Monoclonal antibody 323A3 临床一期 Centocor, Nonindustrial source 乳腺癌, 癌症
Edrecolomab 撤市 强生, 葛兰素史克, 味之素 结肠直肠癌 详情
Solitumomab AMG-110; MT-110 临床一期 Micromet 实体瘤 详情
Adecatumumab MT-201,MT201 临床二期 安进, 默克雪兰诺 前列腺癌, 乳腺癌, 结肠直肠癌 详情

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