Integrin alpha L beta 2 Molecule Synonym Name
Integrin alpha L beta 2, ITGAL&ITGB2
Integrin alpha L beta 2 分子背景
Integrin alpha-L beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin alpha L beta 2 is also a receptor for F11R (By similarity). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating the role in lymphopoiesis. Integrin alpha L beta 2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.
Integrin alpha L beta 2 参考文献
Kaufmann Y., et al. 1991, J Immunol., 147(1), 369-74.
Liu Z., et al. 2006, Blood.,107(3), 1063-9.
Bose TO., et al. 2014, J Immunol., 193(6), 2863-72.