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TPBG信息

英文名称:Trophoblast glycoprotein
中文名称:5T4滋养层糖蛋白
靶点别称:Trophoblast glycoprotein,Wnt-activated inhibitory factor 1,5T4,WAIF1,M6P1,5T4 oncotrophoblast glycoprotein,5T4 oncofetal trophoblast glycoprotein,TPBG,5T4 oncofetal antigen
上市药物数量:0
临床药物数量:8
最高研发阶段:临床三期

TPBG产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
TPG-H82Eb
Human
Biotinylated Human TPBG / 5T4 Protein, His,Avitag
TPG-H52E5
Human
Unconjugated Human TPBG / 5T4 Protein, His,Avitag
 
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TPBG Molecule Synonym Name

TPBG,5T4, M6P1,5T4AG,WAIF1,5T4M6P1,WAIF1,5T4 oncofetal antigen,Trophoblast glycoprotein,5T4 oncofetal trophoblast glycoprotein

TPBG 分子背景

Trophoblast glycoprotein (TPBG), also known as 5T4, is the therapeutic target of several anticancer agents currently in clinical development, largely due to its high expression in tumors and low expression in normal adult tissues.This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. TPBG is expressed by all types of trophoblasts as early as 9 weeks of development.

TPBG 参考文献

TPBG临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
SYD-1875 SYD-1875 临床一期 Synthon 实体瘤 详情
Prostate cancer vaccine, inactivated viral (University of Oxford) 临床阶段不明 牛津大学 前列腺癌
CME-548 (Oxford biomedica/Pfizer) CME-548 临床前 牛津生物医药, 辉瑞 癌症
GEN-1044 GEN-1044 临床二期 Genmab 实体瘤 详情
OXB-301 OXB-301; SAR-109659 临床三期 牛津生物医药, Cardiff University, 英国伦敦大学学院, Wales Cancer Trials Unit 肾透明细胞癌 详情
PET imaging agent (ImaginAb/Oxford BioMedica) 临床前 ImaginAb, 牛津生物医药 卵巢癌
PF-06263507 PF-06263507 临床一期 牛津生物医药, 辉瑞 实体瘤 详情
Naptumomab estafenatox ABR-217620; TTS-CD3,ABR217620,TTSCD3 临床三期 Active Biotech 晚期肾细胞癌 详情

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