Integrin alpha 4 beta 1 Molecule Synonym Name
Integrin alpha 4 beta 1, ITGA4&ITGB1
Integrin alpha 4 beta 1 Molecule Background
Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. Integrin alpha 4 beta 1(Alpha-4/beta-1) is receptors for fibronectin. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1.
Integrin alpha 4 beta 1 References
- May AE., et al.2000, Blood., 96(2), 506-13.
- Luo BH., et al.2007, Annu Rev Immunol., 25, 619-47.
- akada, Y., et al. 2007 Genome Biol., 8(5), 215.