B7-H5 靶点蛋白|抗体药物|临床药物信息

B7-H5信息

英文名称：V-domain Ig suppressor of T-cell activation
中文名称：T细胞活化的免疫球蛋白抑制V型结构域
靶点别称：Dies1，Stress-induced secreted protein-1，PP2135，SISP1，UNQ730/PRO1412，V-type immunoglobulin domain-containing suppressor of T-cell activation，V-Set Immunoregulatory Receptor，V-Domain Ig Suppressor Of T Cell Activation，PDCD1 Homolog，C10orf54，Sisp-1，VISTA，Chr

上市药物数量：0
临床药物数量：2
最高研发阶段：临床二期

B7-H5产品列表

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产品库

在线 (7)

物种

标签

属性

Protein (7)

标记

货号	物种	产品描述
B75-H82E1	Human	Biotinylated Human B7-H5 / Gi24 / VISTA Protein, Avitag,His Tag
B75-H52H0	Human	Human B7-H5 / Gi24 / VISTA Protein, His Tag (MALS verified)
B75-H5259	Human	Human B7-H5 / Gi24 / VISTA Protein, Fc Tag
B75-C5220	Rhesus macaque	Rhesus macaque B7-H5 / Gi24 / VISTA Protein, His Tag
B75-M52H7	Mouse	Mouse B7-H5 / Gi24 / VISTA Protein, His Tag
B75-H82F3	Human	Biotinylated Human B7-H5 / Gi24 / VISTA Protein, Fc,Avitag
B75-H5258	Human	Human B7-H5 / Gi24 / VISTA Protein, Mouse IgG2a Fc Tag, low endotoxin

B7-H5 分子别名

B7-H5,SISP1,Gi24,VISTA

B7-H5 分子背景

Platelet receptor Gi24, also known as B7-H5 and stress-induced secreted protein-1 (Sisp-1), is a protein that in humans is encoded by the C10orf54 gene, which contains 1 Ig-like (immunoglobulin-like) domain. As for C10orf54 gene, C10orf54 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state on ESCs. Human C10orf54 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment.

B7-H5 参考文献

B7-H5临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Onvatilimab	CI-8993; JNJ-61610588	临床一期	杨森, Immunext	肿瘤	详情
CA-170	CA-170; AUPM-170	临床二期	Aurigene	实体瘤, 肿瘤	详情

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B7-H5 重组蛋白