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 > 【B7-H5】重组蛋白信息

B7-H5信息

英文名称:V-domain Ig suppressor of T-cell activation
中文名称:T细胞活化的免疫球蛋白抑制V型结构域
靶点别称:Dies1,Stress-induced secreted protein-1,PP2135,SISP1,UNQ730/PRO1412,V-type immunoglobulin domain-containing suppressor of T-cell activation,V-Set Immunoregulatory Receptor,V-Domain Ig Suppressor Of T Cell Activation,PDCD1 Homolog,C10orf54,Sisp-1,VISTA,Chr
上市药物数量:0
临床药物数量:2
最高研发阶段:临床二期

B7-H5 分子别名

B7-H5,SISP1,Gi24,VISTA

B7-H5 分子背景

Platelet receptor Gi24, also known as B7-H5 and stress-induced secreted protein-1 (Sisp-1), is a protein that in humans is encoded by the C10orf54 gene, which contains 1 Ig-like (immunoglobulin-like) domain. As for C10orf54 gene, C10orf54 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state on ESCs. Human C10orf54 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment.

B7-H5 参考文献

B7-H5临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Onvatilimab CI-8993; JNJ-61610588 临床一期 杨森, Immunext 肿瘤 详情
CA-170 CA-170; AUPM-170 临床二期 Aurigene 实体瘤, 肿瘤 详情

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