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LAIR-1产品列表

 
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LA1-H5252|Human LAIR1 / CD305 Protein, Fc Tag
  1. 135XXXXXXX7
  2. 0人赞
  3. 赶上公司做活动 做SPR还可以免费用他们家的蛋白 感觉简直是太赚了 第一次就做出来了 为了稳定结果 我要求重复几次 公司的技术老师很负责 直到做到满意为止 蛋白也好用 价格也不贵
  4. 2020-02-20
 

LAIR-1 分子别名

LAIR1,CD305

LAIR-1 分子背景

Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell–mediated cytotoxicity. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism.

LAIR-1 参考文献

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