Integrin isoform alpha-7X2B beta 1 分子别名
Integrin isoform alpha-7X2B beta 1,ITGA7X2BB1,ITGA7X2B&ITGB1,ITGA7X2B&B1
Integrin isoform alpha-7X2B beta 1 分子背景
Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers, which is highly expressed in cardiac muscle, skeletal muscle and smooth muscle cells, and localizes to Z-disc and costamere structures. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). ITGA7 has been shown to interact with Merosin, ITGB1, FHL2 and FHL3.
Integrin isoform alpha-7X2B beta 1 参考文献
- Hodges, BL., et al., 1997, Journal of Cell Science, 110 (22): 2873-2881.
- Mielenz, D., et al., 2001, The Journal of Biological Chemistry, 276 (16): 13417-13426.
- Samson T., et al., 2004, J. Biol. Chem. 279 (27): 28641-28652.