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TGF-beta 1信息

英文名称:Transforming growth factor beta 1
中文名称:转化生长因子β1
靶点别称:TGFbeta,Transforming Growth Factor Beta 1,Diaphyseal Dysplasia 1, Progressive,TGF-Beta1,IBDIMDE,Transforming Growth Factor beta1,Latency-Associated Peptide,TGFB,CED,DPD1,Transforming Growth Factor, Beta 1,TGF-Beta-1,Prepro-Transforming Growth Factor Beta-
上市药物数量:1
临床药物数量:10
最高研发阶段:批准上市

TGF-beta 1产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
TG1-H4212
Human
ActiveMax® Human TGF-Beta 1 / TGFB1 Protein, Tag Free
TG1-H8217
Human
Biotinylated Human TGF-Beta 1 / TGFB1 Protein, Avitag™
TG1-M5218
Mouse
Mouse TGF-Beta 1 / TGFB1 Protein
 
评论(1)
TG1-H4212|ActiveMax® Human TGF-Beta 1 / TGFB1 Protein, Tag Free
  1. 152XXXXXXX2
  2. 4人赞
  3. 使用过该TGFb1蛋白用来做为T细胞抑制实验中的阴性对照组,该蛋白具有很好的抑制T细胞的活性,能够明显地抑制由anti-CD3刺激的T细胞的增殖,而且实验重复性和稳定性都不错。
  4. >
  5. 2019-10-12
 

TGF-beta 1 Molecule Synonym Name

CEDLAP,TGF-beta 1,TGFB1,DPD1,TGF-beta-1,TGFB

TGF-beta 1 分子背景

Transforming growth factor beta 1 ( TGFB1) is also known as TGF-β1, CED, DPD1, TGFB. is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The TGFB1 protein helps control the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (motility), and the self-destruction of cells (apoptosis). The TGFB1 protein is found throughout the body and plays a role in development before birth, the formation of blood vessels, the regulation of muscle tissue and body fat development, wound healing, and immune system function. TGFB1 is particularly abundant in tissues that make up the skeleton, where it helps regulate bone growth, and in the intricate lattice that forms in the spaces between cells (the extracellular matrix). Within cells, this protein is turned off (inactive) until it receives a chemical signal to become active. TGFB1 plays an important role in controlling the immune system, and shows different activities on different types of cell, or cells at different developmental stages. Most immune cells (or leukocytes) secrete TGFB1. TGFB1 has been shown to interact with TGF beta receptor 1, LTBP1, YWHAE, EIF3I and Decorin.

TGF-beta 1 参考文献

TGF-beta 1上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Pirfenidone 吡非尼酮 F-647; AMR-69; GP-101; S-7701; S-770108; RO-0220912 批准上市 Intermune 艾思瑞, Deskar, Etuary, Esbriet, Pirespa, Aisuryui United States 特发性肺纤维化 Genentech Inc 2008-10-16 放射性肺炎, 肾功能不全, 皮肌炎, 特发性肺纤维化, 系统性硬皮病, 肺纤维化, 间质性肺疾病, 糖尿病肾病, 外源性变应性肺泡炎, 尘肺 详情

TGF-beta 1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Nicousamide XLF-III-43 临床二期 中国医学科学院药物研究所 高血压肾病, 糖尿病肾病
盐酸美氟尼酮 临床一期 广州南鑫药业有限公司, 中南大学 糖尿病肾病
DW-1029M DW-1029M 临��二期 同和药品 糖尿病肾病 详情
Disitertide P-144; NAFB-001; Peptide-144 临床二期 Digna Biotech, University Of Navarra 纤维化, 系统性硬皮病 详情
Fluorofenidone AKF-PD 临床一期 达瑞医药香港有限公司, 海南海药股份有限公司, 中南大学 肝硬化, 肾脏纤维化
Bintrafusp alfa M-7824; GSK-4045154; MSB-0011359C 临床三期 默克雪兰诺 胆管癌, 三阴性乳腺肿瘤, 胆管上皮癌, 胆囊癌, 非小细胞肺癌, 宫颈癌 详情
YL-13027 YL-13027 临床一期 上海璎黎药业有限公司 实体瘤 详情
STP-705 STP-705; STP-705L; STP-705LU; STP-705LV 临床二期 苏州圣诺生物医药技术有限公司, 美国圣诺制药公司 肝癌, 鲍温病, 基底细胞癌, 胆管上皮癌, 鳞状细胞癌, 皮肤增生性瘢痕, 肝细胞癌 详情
Vactosertib EW-7197; NOV-1301; TEW-7197 临床二期 Medpacto 实体瘤, 胃癌, 食道癌, 骨髓增生异常综合征, 移行细胞癌, 泌尿系肿瘤, 结直肠癌, 腺癌, 非小细胞肺癌 详情
Yinfenidone Hydrochloride HEC-585; HEC-00000585 临床二期 宜昌东阳光药业股份有限公司 特发性肺纤维�� 详情

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