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SCARB1信息

英文名称:Scavenger receptor class B member 1
中文名称:清道夫受体B类成员-1
靶点别称:SRB1,Collagen type I receptor, thrombospondin receptor-like 1,Scavenger receptor class B member 1,CD_antigen=CD36,SCARB1,CD36 antigen-like 1,CLA-1,CLA1,CD36L1 ,SR-BI,CD36 and LIMPII analogous 1
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

SCARB1产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
SC1-H5258
Human
Human SCARB1 /CD36L1 /SR-BI Protein, With C-Fc Tag
 
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SCARB1 分子别名

SCARB1,CD36L1,SRB1,CLA-1,SR-BI,HDLQTL6

SCARB1 分子背景

Scavenger receptor class B member 1 (SRB1) is also known as SR-BI, CD36 and LIMPII analogous 1 (CD36L1), CLA-1, is a member of the scavenger receptor family or CD36 family. CD36L1 is an integral membrane protein found in numerous cell types/tissues, including the liver and adrenal. SRB1 is receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. CLA-1 facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as high-density lipoprotein (HDL) and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. SCARB1 is, along with CD81, the receptor for the entry of the Hepatitis C virus glycoprotein E2 in liver cells, and binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. SRB1 plays an important role in the uptake of HDL cholesteryl ester.

SCARB1 参考文献

SCARB1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
ITX-5061 ITX-5061,ITX5061 临床二期 iTherX 丙肝 详情

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