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ROR1信息

英文名称:Tyrosine-protein kinase transmembrane receptor ROR1
中文名称:蛋白酪氨酸激酶跨膜受体ROR1
靶点别称:mROR1,Ntrkr1,Ror1,Neurotrophic tyrosine kinase, receptor-related 1,Inactive tyrosine-protein kinase transmembrane receptor ROR1
上市药物数量:0
临床药物数量:0
最高研发阶段

ROR1 分子别名

ROR1,NTRKR1

ROR1 分子背景

Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.

ROR1 参考文献

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