搜索
 > 【Neuregulin-4】重组蛋白信息

Neuregulin-4产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
NR4-H52H3
Human
Human Neuregulin-4 / NRG4 Protein, His Tag

Neuregulin-4 分子别名

Neuregulin-4,NRG4

Neuregulin-4 分子背景

Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene. Loss of expression of NRG4 is frequently seen in advanced bladder cancer while increased NRG4 expression correlates to better survival. The neuregulins, including NRG4, activate type-1 growth factor receptors (EGFR) to initiating cell-to-cell signaling through tyrosine phosphorylation. Furthermore, NRG4 is a low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG4 does not bind to the ERBB1, ERBB2 and ERBB3 receptors.

Neuregulin-4 参考文献

消息提示

请输入您的联系方式,再点击提交!

确定