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 > 【Nectin-3】重组蛋白信息

Nectin-3产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
PV3-H52E4
Human
Human Nectin-3 / CD113 Protein
PV3-H5255
Human
Human Nectin-3 / CD113 Protein, Fc Tag
PV3-H82F3
Human
Biotinylated Human Nectin-3 / CD113 Protein, Fc,Avitag

Nectin-3 分子别名

CD113,Nectin-3,PVRL3

Nectin-3 分子背景

Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the immunoglobulin superfamily which forms part of adherens junctions. Nectins are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin system in epithelial cells. PVRL3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Furthermore, PVRL3 induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation.

Nectin-3 参考文献

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