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 > 【LIF R】重组蛋白信息

LIF R信息

英文名称:LIFR/GP130
中文名称:LIFR/GP130蛋白相互作用
靶点别称:CD_antigen=CD118,Oncostatin-M receptor subunit alpha,CD_antigen=CD130,IL-6R-beta,gp130,Interleukin-6 signal transducer,Membrane glycoprotein 130,IL-6R subunit beta,Leukemia inhibitory factor receptor,Interleukin-6 receptor subunit beta,LIFR,LIF-R,LIF rece
上市药物数量:0
临床药物数量:2
最高研发阶段:临床二期

LIF R产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
LIR-H4252
Human
Human-LIFR-CD118-Protein-C-Fc Tag

LIF R 分子别名

LIFR,CD118,FLJ98106,FLJ99923,SJS2,STWS,SWS

LIF R 分子背景

Leukemia inhibitory factor receptor is also known as LIFR; CD118; FLJ98106; FLJ99923; LIF-R; SJS2; STWS; SWS, is the receptor for leukemia inhibitory factor (LIF). The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS), a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias.

LIF R 参考文献

LIF R临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Cardiotrophin-1 (Digna Biotech/Biotecnol) CT-1 临床二期 Biotecnol SA, Digna Biotech, 基因泰克 心脏再灌注损伤, 急性肾损伤, 缺血 详情
Emfilermin AM-424 临床二期 Walter and Eliza Hall Institute of Medical Research, 默克雪兰诺, Zenyth 神经肌肉疾病, 不孕症 详情

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