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Leptin R信息

英文名称:Leptin receptor
中文名称:瘦素受体
靶点别称:LEP-R,Leptin receptor,OBR,CD_antigen=CD295,DB ,OB-R,LEPR,OB receptor,HuB219
上市药物数量:1
临床药物数量:2
最高研发阶段:批准上市

Leptin R产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
LER-H5252
Human
Recombinant Human Leptin R / CD295 Protein

Leptin R 分子别名

LEPR,CD295,DKFZp686B1731,OBR,Leptin receptor

Leptin R 分子背景

Leptin receptor (LEPR) is also known as LEP-R, cluster of differentiation 295 (CD295), OB-R and B219, is a single-transmembrane-domain receptor of the gp130 family of cytokine receptors. Leptin receptor exists as homodimer and binds Leptin with high affinity, thus mediates the biological function of the adipocyte-specific hormone Leptin. LEPR is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this protein have been associated with obesity and pituitary dysfunction. Interaction of leptin and leptin receptor is crucial for body weight and bone mass regulation in mammals through hypothalamic effects on satiety and energy expenditure. Meanwhile, research data supports a leptin receptor activation model based on ligand-induced conformational changes.

Leptin R 参考文献

Leptin R上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Metreleptin 美曲普汀 AC-164594; KTR-103 批准上市 Amylin Pharmaceutical, 阿斯利康, 百时美施贵宝, Aegerion, 盐野义 Metreleptin 日本 脂肪代谢障碍 盐野义 2013-03-25 00:00:00.0 脂肪代谢障碍 详情

Leptin R临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
REGN-4461 REGN-4461 临床一期 再生元制药 肥胖症, 脂肪代谢障碍 详情
Metreleptin/Pramlintide Acetate AC-137-164594 临床二期 Amylin Pharmaceutical, 武田 肥胖症

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