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ICOS信息

英文名称:Inducible T-cell costimulator
中文名称:诱导T细胞共刺激分子
靶点别称:CD278,ICOS,Activation-inducible lymphocyte immunomediatory molecule,AILIM
上市药物数量:0
临床药物数量:6
最高研发阶段:临床二期

ICOS Molecule Synonym Name

ICOS,CD278,AILIM,Inducible T-cell costimulator

ICOS 分子背景

Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.

ICOS 参考文献

ICOS临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
XmAb-23104 (Xencor) 临床一期 Xencor 实体瘤 详情
GSK-3359609 GSK-3359609 临床二期 葛兰素史克 非小细胞肺癌, 实体瘤 详情
MEDI-570 (Japan Tobacco) 临床一期 日本烟草, MedImmune 系统性红斑狼疮 详情
Anti-ICOS (Bristol Myers Squibb) BMS-986226 临床一期 百时美施贵宝 癌症
KY-1044 KY-1044 临床二期 Kymab 胃癌, 非小细胞肺癌, 食道癌, 乳腺癌, 肝癌, 鳞状细胞癌, 肾癌, 头颈癌, 宫颈癌, 胰腺癌, 黑色素瘤 详情
Vopratelimab JTX-2011 临床二期 Jounce Therapeutics, 新基 非小细胞肺癌, 尿路上皮癌, 实体瘤 详情

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