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ICAM-1信息

英文名称:Intercellular adhesion molecule-1
中文名称:细胞间粘附分子-1
靶点别称:Major group rhinovirus receptor,Intercellular adhesion molecule 1,ICAM1,ICAM-1,CD_antigen=CD54
上市药物数量:1
临床药物数量:12
最高研发阶段:批准上市

ICAM-1产品列表

产品库
物种
属性
货号 物种 产品描述 蛋白结构 纯度 活性
IC1-H5250
Human
Recombinant Human ICAM-1 / CD54 Protein
IC1-H52H5
Human
Human ICAM-1 / CD54 Protein, His Tag
 
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ICAM-1 分子别名

ICAM1,BB2,CD54,P3.58

ICAM-1 分子背景

Inter-Cellular Adhesion Molecule 1 (ICAM-1) is also known as Cluster of Differentiation 54 (CD54), is a member of the immunoglobulin superfamily, and is a cell surface glycoprotein which is typically expressed in low concentrations on endothelial cells and cells of the immune system. The protein encoded by this gene is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. Upon cytokine stimulation, the concentrations greatly increase. ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFα) and is expressed by the vascular endothelium, macrophages, and lymphocytes. ICAM-1 is a ligand for LFA-1 (integrin), a receptor found on leukocytes. When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 and then transmigrate into tissues. ICAM-1 has been implicated in subarachnoid hemorrhage (SAH). Levels of ICAM-1 are shown to be significantly elevated in patients with SAH over control subjects in many studies. ICAM-1 expressed by respiratory epithelial cells is also the binding site for rhinovirus, the causative agent of most common colds.

ICAM-1 参考文献

ICAM-1上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Tocopherol acetate 生育酚醋酸酯 DSE-9912 批准上市 未知 静脉血栓栓塞, 间歇性跛行, 糖尿病视网膜病变, 动脉粥样硬化事件的预防, 血栓 详情

ICAM-1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Enlimomab 临床三期 勃林格殷格翰 中风, 自身免疫疾病, 糖尿病, 移植物抗宿主病, 颅内血栓形成, 肝脏移植排斥反应, 心肌缺血, 类风湿性关节炎, 烧伤, 哮喘, 肾移植排斥反应
GI-270384X GI-270384X; GI-270384 临床二期 葛兰素史克 炎症性肠病 详情
BAY-Z-9700 BAY-Z-9700 临床一期 拜耳 鼻炎, 哮喘
AIC-100 AIC-100,AIC100 临床一期 AffyImmune Therapeutics 甲状腺癌
RhinoRx (Planet Biotechnology) 临床前 Planet Biotechnology 人鼻病毒(HRV)感染
ICM-3 ICM-3 临床二期 ICOS Corporation 银屑病
tICAM-1-453 (Bayer) 临床一期 拜耳 人鼻病毒(HRV)感染
Coxsackievirus A21 (Viralytics) CVA-21; V-937 临床二期 Viralytics 黑色素瘤 详情
Tyroserleutide CMS-024; YSL; alpha-BCP[7-9],CMS024 NDA 申请 康哲药业 肝细胞癌 详情
Bersanlimab BI-505 临床二期 BioInvent International 多发性骨髓瘤 详情
Alicaforsen sodium AP-1007; AP-1431; AP-1450; AP-1451; ISIS-2302 NDA 申请 Ionis Pharmaceuticals, Atlantic Healthcare 溃疡性结肠炎, 贮袋炎, 炎症性肠病 详情
DZ-13 DZ-13; DZ13 临床一期 新南威尔士大学, 皇家阿尔弗雷德王子医院 基底细胞癌, 转移性黑色素瘤

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