Fetuin A 分子别名
Fetuin A 分子背景
Alpha-2-HS-glycoprotein (AHSG) is also known as Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein, Fetuin-A (FETUA), is a glycoprotein that is composed of two subunits, the A and B chains, belongs to the cystatin family of proteases inhibitors and the fetuin class of plasma binding proteins. AHSG / Fetuin A is highly expressed in embryonic cells and adult hepatocytes, and is expressed to a lesser extent in monocytes/macrophages. Fetuins are carrier proteins like albumin. Fetuin-A / AHSG forms soluble complexes with calcium and phosphate and thus is a carrier of otherwise insoluble calcium phosphate. Thus AHSG / Fetuin A is a potent inhibitor of pathological calcification. Fetuin A / FETUA promotes phagocytosis of apoptotic cells and plays a role in bone development, calcium homeostasis and insulin sensitivity. Mice deficient in Fetuin-A show systemic calcification of soft tissues.
Fetuin A 参考文献
- Jahnen-Dechent W., et al., 1994, Eur. J. Biochem. 226 (1): 59–69.
- Lee C., et al., 2009, Frontiers in Bioscience 14: 2911–2922.
- Heiss A., et al., 2008, J. Biol. Chem. 283 (21): 14815–25.
- Jahnen-Dechent W., et al., 2008, J. Mol. Med. 86 (4): 379–89.