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CD74信息

英文名称:HLA-DR antigens-associated invariant chain
中文名称:HLA-DR抗原相关不变链
靶点别称:CLIP,CD74,Ia antigen-associated invariant chain,CD74 Molecule,CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility Complex, Class II Antigen-Associated),CD74 Molecule, Major Histocompatibility Complex, Class II Invariant Chain,HLA-DR Antigens-A
上市药物数量:0
临床药物数量:3
最高研发阶段:临床二期

CD74产品列表

物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
CD4-H524c
Human
Human CD74 / DHLAG Protein, His Tag
CD4-H5224
Human
Human CD74 / DHLAG Protein, His Tag
 
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CD74 Molecule Synonym Name

CD74,DHLAG,HLADG,II,Ia-GAMMA,p33,CLIP,INVG34

CD74 分子背景

Cluster of Differentiation 74 (CD74) is also known as HLA class II histocompatibility antigen gamma chain (HLADG), DHLAG, Ia-GAMMA, invariant chain (Abbreviated Ii). CD74 / HLADG is a polypeptide involved in the formation and transport of MHC class II protein. The cell surface form of the invariant chain is known as CD74. CD74 is upregulated in several cancers and is also expressed by non-immune cells during inflammation. CD74 plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha / beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal / lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. CD74 / DHLAG also serves as cell surface receptor for the cytokine MIF.

CD74 参考文献

CD74临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Influenza A M1 vaccine (Pascal Biosciences) 临床一期 Pascal Biosciences 甲型流感病毒感染
Milatuzumab hLL1; hCD74; IMMU-115 临床二期 Immunomedics 慢性髓细胞白血病, 盘状红斑狼疮, 淋巴细胞性白血病, 浆细胞瘤, 骨髓增生异常综合征, 皮肤红斑狼疮, 移植物抗宿主病, 狼疮肾炎, 多发性骨髓瘤, 系统性红斑狼疮, 急性淋巴细胞白血病, 狼疮血管炎,中枢神经系统, 非霍奇金淋巴瘤, 慢性淋巴细胞白血病 详情
Anti-CD 74 antibody drug conjugates(Sutro Biopharma) STRO-001 临床一期 Sutro Biopharma B-细胞淋巴瘤, 弥漫性大B-细胞淋巴瘤, 多发性骨髓瘤, 滤泡中心淋巴瘤, 套细胞淋巴瘤, 淋巴瘤, 非霍奇金淋巴瘤 详情

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