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CD5信息

英文名称:T-cell surface glycoprotein CD5
中文名称:T细胞表面糖蛋白CD5
靶点别称:T-cell surface glycoprotein CD5,Lymphocyte antigen T1/Leu-1,CD5,CD_antigen=CD5,LEU1
上市药物数量:0
临床药物数量:2
最高研发阶段:临床三期

CD5产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
CD5-H52H5
Human
Recombinant Human CD5 / LEU1 Protein

CD5 分子别名

CD5,LEU1

CD5 分子背景

T-cell surface glycoprotein CD5 is also known as Lymphocyte antigen T1/Leu-1 and LEU1,which is phosphorylated on tyrosine residues by LYN,so CD5 can create binding sites for PTPN6/SHP-1.CD5 may act as a receptor in regulating T-cell proliferation. CD5 is expressed at various developmental and activation stages on human B cells.CD5 is a well established negative regulator of TCR and BCR signalling.CD5-positive cells may also prevent the emergence of autoimmunity by provision of cytokines such as IL-10. Development,selection and function of different B- and T-cell subsets or their preferential survival may be directly or indirectly dependent on different glycan structures associated with CD5 or CD5-like molecules.

CD5 参考文献

CD5临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Monoclonal antibody T101-Y-90 conjugate 临床一期 Nonindustrial source, Hybritech Incorporated 血液系统恶性肿瘤
Zolimomab aritox 临床三期 Cancer Research UK, Xoma, Ortho-McNeil 糖尿病, 移植物抗宿主病, 类风湿性关节炎, 肾移植排斥反应

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