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 > 【CD46】重组蛋白信息

CD46信息

英文名称:Membrane cofactor protein
中文名称:膜辅因子蛋白
靶点别称:MCP,TLX,Trophoblast leukocyte common antigen,MIC10,CD46
上市药物数量:0
临床药物数量:4
最高研发阶段:临床二期

CD46产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
CD6-H5226
Human
Human CD46 Protein, His Tag

CD46 分子别名

CD46,AHUS2,MCP,MIC10,TLX,TRA2.10

CD46 分子背景

Complement regulatory protein CD46 is also known as membrane Cofactor Protein (MCP), is a type I membrane protein and is a regulatory part of the complement system. CD46 is expressed by all cells except erythrocytes. MCP acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue, and also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2).

CD46 参考文献

CD46临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Enadenotucirev ColoAd-1; Oncolytic Ad11/Ad3 临床二期 PsiOxus Therapeutics, 默沙东 实体瘤, 结肠直肠癌, 膀胱癌, 卵巢癌 详情
Carcinoembryonic antigen-expressing measles virus (National Cancer Institute) 临床一期 美国国立癌症研究所 神经胶质瘤, 成胶质细胞瘤, 原发性腹腔癌, 卵巢癌, 间变性星形细胞瘤 详情
AugmAb BRM-132 临床一期 全福生物科技, PAI Life Sciences 癌症 详情
FOR-46 FOR-46,FOR 46,FOR46 临床一期 圣迭戈加利福尼亚大学 前列腺癌, 多发性骨髓瘤 详情

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