CD30 靶点蛋白|抗体药物|临床药物信息

CD30信息

英文名称：Tumor necrosis factor receptor superfamily member 8
中文名称：肿瘤坏死因子受体超家族成员8
靶点别称：TNFRSF8，Lymphocyte activation antigen CD30，D1S166E，CD30L receptor，Tumor necrosis factor receptor superfamily member 8，CD30 ，Ki-1 antigen，CD_antigen=CD30

上市药物数量：1
临床药物数量：11
最高研发阶段：批准上市

CD30产品列表

货号	物种	产品描述
CD0-H5229	Human	Recombinant Human CD30 / TNFRSF8 Protein
CD0-H5250	Human	Recombinant Human CD30 / TNFRSF8 Protein
CD0-H82E6	Human	Biotinylated Human CD30 / TNFRSF8 Protein, His Tag, Avi Tag
TN8-H5250	Human	Human CD30 / TNFRSF8 Protein, Llama IgG2b Fc Tag, low endotoxin

CD30 分子别名

TNFRSF8,CD30,D1S166E,Ki-1

CD30 分子背景

Human CD30 is also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. TNFRSF-8 is expressed by activated, but not by resting, T and B cells. Also, CD30 is expressed on classical Hodgkin Lymphoma cells together with CD15. CD30 is the receptor for TNFSF8/CD30L. CD30 can interact with TRAF2 and TRAF5, and mediate the signal transduction that leads to the activation of NF-kappa-B. TNFRSF8 may play a role in the regulation of cellular growth and transformation of activated lymphoblasts. TNFRSF8 is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.

CD30 参考文献

CD30上市药物信息

英文名称	中文名称	研发代码	研发阶段	公司	最早商品名	最早批准国家	最早适应症	最早批准公司	最早批准日期	适应症	临床试验
Brentuximab vedotin		SGN-35; SGN-30; cAC-10; SGD-1010; cAC10-vcMMAE; cAC10-Val-Cit-MMAE,SGN35,SGN30,cAC-10,SGD1010	批准上市	Seattle Genetics, 千年制药	ADCETRIS	fda	系统间变性大细胞淋巴瘤, 霍奇金淋巴瘤	SEATTLE GENETICS	2011-08-19	套细胞淋巴瘤, 系统间变性大细胞淋巴瘤, 霍奇金淋巴瘤	详情

CD30临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Anti-CD30 monoclonal antibody BerH2		临床一期	Nonindustrial source, Medac	霍奇金淋巴瘤
XmAb-2513	XmAb-2513	临床一期	Xencor	T细胞淋巴母细胞淋巴瘤, 霍奇金淋巴瘤	详情
Iratumumab	MDX-060; MAb-5F11; anti-CD30	临床二期	Medarex	淋巴瘤, 非霍奇金淋巴瘤, 霍奇金淋巴瘤	详情
SGN 30	SGN-30	临床二期	Seattle Genetics	皮肤T细胞淋巴瘤, 霍奇金淋巴瘤	详情
CD30.CAR	CD30.CAR; H-27721	临床一期	贝勒医学院, bluebird bio	非霍奇金淋巴瘤, 霍奇金淋巴瘤
Anti-CD64-anti-CD30 bispecific monoclonal antibody (Medarex)		临床一期	Medarex	霍奇金淋巴瘤
Anti-CD16-anti-CD30 monoclonal antibody		临床二期	Biotest	霍奇金淋巴瘤
AFM-13	AFM-13	临床二期	University of Texas M. D. Anderson Cancer Center, Affimed	霍奇金淋巴瘤	详情
EBV-specific-CAR.CD30	EBV-specific-CAR.CD30; CAR.CD30 EBV-specific-CTLs	临床一期	贝勒医学院, 德克萨斯儿童医院, 卫理公会医院	非霍奇金淋巴瘤, 霍奇金淋巴瘤	详情
MDX-1401	MDX-1401	临床一期	Medarex	霍奇金淋巴瘤	详情
Recombinant chimeric anti-CD30 monoclonal antibody-MCC-DM1		临床申请	上海复旦张江生物医药	实体瘤

会议日历

会议一览

CD30 重组蛋白