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CD28信息

英文名称:T-cell-specific surface glycoprotein CD28
中文名称:T细胞特异性表面糖蛋白CD28
靶点别称:CD28,T-cell-specific surface glycoprotein CD28,TP44,CD_antigen=CD28
上市药物数量:0
临床药物数量:15
最高研发阶段:临床三期

CD28产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
CD8-M52H6
Mouse
Mouse CD28 Protein, His Tag
CD8-M5257
Mouse
Mouse CD28 Protein, C-Fc Tag
CD8-H82F2
Human / Cynomolgus / Rhesus macaque
Biotinylated Human / Cynomolgus / Rhesus macaque CD28 Protein, Fc,Avitag
CD8-H52A5
Human / Cynomolgus / Rhesus macaque
Human / Cynomolgus / Rhesus macaque CD28 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD8-H525a
Human / Cynomolgus / Rhesus macaque
Human / Cynomolgus / Rhesus macaque CD28 Protein, Fc Tag (HPLC-verified)
CD8-H52Hc
Human / Cynomolgus / Rhesus macaque
Human / Cynomolgus / Rhesus macaque CD28 Protein

CD28 分子别名

CD28,Tp44

CD28 分子背景

T-cell-specific surface glycoprotein CD28 is also known as TP44, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.

CD28 参考文献

CD28临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Anti-BCMA CAR T cell therapy (Wuhan Bio-Raid Biotechnology) 临床阶段不明 武汉波睿达生物科技有限公司 血液系统恶性肿瘤
Abatacept (Orban Biotech) 临床二期 国家糖尿病消化与肾脏病研究院, Orban Biotech 1型糖尿病 详情
FPT-155 CD80-Fc; FPT-155 临床一期 Five Prime Therapeutics 实体瘤
Autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T cells (City of Hope Medical Center) 临床一期 希望之城国家医疗中心 非霍奇金淋巴瘤
Recombinant CD28 (CytoMed) 临床阶段不明 CytoMed 自身免疫疾病, 类风湿性关节炎, 过敏性疾病, 预防器官排斥反应
TGN-1412 TGN-1412 临床一期 TeGenero 癌症
Lulizumab pegol BMS-931699; Lulizumab 临床二期 百时美施贵宝 干燥综合征, 系统性红斑狼疮 详情
Anti-CD28/anti-HMV-MAA bispecific antibody (Eberhard-Karls-Universitaet Tuebingen) rM28; r28M 临床二期 蒂宾根大学 癌症
ALPN-101 ALPN-101 临床一期 Alpine Immune Sciences 噬血细胞淋巴组织细胞增多症, 自身免疫疾病, 炎症 详情
ALPN-202 ALPN-202 临床前 Alpine Immune Sciences 癌症
B7-2/GM-CSF cancer gene therapy CIT 临床一期 Radient 实体瘤
FR-104 FR-104; JNJ-3133,FR104; JNJ3133 临床二期 Effimune, 杨森, Biomedical Primate Research Center, OSE Immunotherapeutics 移植排斥反应, 类风湿性关节炎 详情
Theralizumab TAB-08; TABO-8 临床二期 TheraMAB 斑块状银屑病, 系统性红斑狼疮 详情
Membrane bound ligand T-SIGn virus NG-348 临床一期 PsiOxus Therapeutics, 百时美施贵宝 实体瘤
Reltecimod AB-103; P2TA,AB103 临床三期 Atox Bio 急性肾损伤, 软组织感染 详情

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