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BAFF信息

英文名称:B-cell-activating factor/B lymphocyte stimulator
中文名称:B细胞活化因子/B淋巴细胞刺激因子
靶点别称:TALL-1,BAFF,B-cell-activating factor,Tumor necrosis factor ligand superfamily member 13B,Tumor necrosis factor ligand superfamily member 13b, membrane form,TNFSF13B,TNF- and APOL-related leukocyte expressed ligand 1,BLyS,BLYS,TALL1,TNFSF20,BAFF ,Tumor nec
上市药物数量:1
临床药物数量:11
最高研发阶段:批准上市

BAFF 分子别名

TNFSF13B,BAFF,BLYS,CD257,DTL,TALL-1,TALL1,THANK,TNFSF20,ZTNF4

BAFF 分子背景

B-cell activating factor (BAFF) is also known as tumor necrosis factor ligand superfamily member 13B , TNFSF13B, BAFF, B Lymphocyte Stimulator (BLyS) , cluster of differentiation 257 (CD257), DTL, TNF- and APOL-related leukocyte expressed ligand (TALL-1), THANK, TNFSF20, ZTNF4, and is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. It is expressed as transmembrane protein on various cell types including monocytes, dendritic cells and bone marrow stromal cells. BAFF is the natural ligand of three unusual tumor necrosis factor receptors named BAFF-R, TACI, and BCMA, all of which have differing binding affinities for it. These receptors are expressed mainly on mature B lymphocytes (TACI is also found on a subset of T-cells and BCMA on plasma cells). TACI binds worst since its affinity is higher for a protein similar to BAFF, called a proliferation-inducing ligand (APRIL). BCMA displays an intermediate binding phenotype and will work with either BAFF or APRIL to varying degrees. Signaling through BAFF-R and BCMA stimulates B lymphocytes to undergo proliferation and to counter apoptosis. All these ligands act as heterotrimers (i.e. three of the same molecule) interacting with heterotrimeric receptors, although BAFF has been known to be active as either a hetero- or homotrimer. BAFF acts as a potent B cell activator and has been shown to play an important role in the proliferation and differentiation of B cells. 

BAFF 参考文献

BAFF上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Belimumab HGS-1006; GSK-1550188; BmAb,HGS1006; GSK1550188 批准上市 葛兰素史克 BENLYSTA fda 系统性红斑狼疮 HUMAN GENOME SCIENCES INC. 2011-03-09 系统性红斑狼疮 详情

BAFF临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Tibulizumab (Eli Lilly) 临床一期 礼来 干燥综合征
hCBE-11 hCBE-11,hCBE11,hCBE 11 临床一期 百健 实体瘤 详情
MEDI-0700 MEDI-0700 临床一期 MedImmune 系统性红斑狼疮
Mitumprotimut T 临床三期 MMRGlobal 滤泡性淋巴瘤, 非霍奇金淋巴瘤 详情
UBP-1213 UBP-1213 临床一期 武汉华鑫康源生物医药(湖北), 上海君实生物医药 系统性红斑狼疮
Blisibimod A-623; AMG-623,A623,AMG623 临床三期 Anthera, Zenyaku Kogyo 系统性红斑狼疮 详情
Tabalumab LY-2127399 临床三期 礼来 肾衰竭, 系统性红斑狼疮, 多发性骨髓瘤, 多发性硬化症, 类风湿性关节炎 详情
RCT-18 RCT-18; RC-18 临床三期 荣昌生物 系统性红斑狼疮, 类风湿性关节炎, 视神经脊髓炎 详情
Atacicept TACI-Ig 临床三期 ZymoGenetics, 默克雪兰诺 慢性淋巴细胞白血病, 红斑狼疮性肾炎, 多发性骨髓瘤, 系统性红斑狼疮, 多发性硬化症, 类风湿性关节炎, 非霍奇金淋巴瘤 详情
AMG-570 AMG-570  临床一期 安进, 阿斯利康 系统性红斑狼疮 详情
BAFF/IL-17 bispecific antibody 临床一期 礼来 免疫性疾病

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