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APCS信息

英文名称:Serum amyloid P-component
中文名称:血清淀粉样蛋白P组分
靶点别称:Serum amyloid P-component,9.5S alpha-1-glycoprotein,SAP,APCS,PTX2,Serum amyloid P-component(1-203)
上市药物数量:0
临床药物数量:4
最高研发阶段:临床二期

APCS产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
APS-H5229
Human
Human APCS / SAP / PTX2 Protein, His Tag

APCS 分子别名

PTX2,APCS,SAMP,SAP,Pentraxin 2

APCS 分子背景

Serum amyloid P-component (SAP) is also known as Pentraxin 2 (PTX2), APCS, which belongs to the pentaxin family. SAP contains one pentaxin domain. PTX2 is a secreted homopentamer protein which is found in serum and urine. SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits. SAP can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. SAP may also function as a calcium-dependent lectin. SAP has certain sequence homology with C-reactive protein (CRP).

APCS 参考文献

APCS临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Miridesap GSK-2315698; GSK-2315698A; Ro-63-8695 临床二期 罗氏, 葛兰素史克, Pentraxin Therapeutics 系统性淀粉样变性 详情
Dezamizumab GSK-2398852 临床二期 Pentraxin Therapeutics, 葛兰素史克 系统性淀粉样变性 详情
Miridesap/Dezamizumab GSK-2315698/GSK-2398852 临床二期 Pentraxin Therapeutics, 葛兰素史克 系统性淀粉样变性 详情
GSK-3039294 GSK-3039294 临床一期 葛兰素史克 淀粉体轻链淀粉样变性 详情

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