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 > 【CRTAM】重组蛋白信息

CRTAM产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
CRM-C5255
Cynomolgus
Cynomolgus CRTAM Protein, Fc Tag
CRM-H52H3
Human
Human CRTAM Protein, His Tag

CRTAM Molecule Synonym Name

CRTAM,CD355

CRTAM 分子背景

Class I-restricted T cell-associated molecule (CRTAM), a member of nectin family and the immunoglobulin superfamily, is also known as cytotoxic and regulatory T-cell molecule, which is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and surprisingly, in brain where it is highly expressed by Purkinje cells of the cerebellum. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions (3 - 5). IGSF4 and T cell receptor co-engagement of CRTAM-expressing CD8+ cells induces increased IFN-gamma or IL-22 production (3, 4). Furthermore, a role in cancer surveillance through NK cell-mediated rejection of IGSF4-expressing tumors has been proposed.

CRTAM 参考文献

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