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 > 【BACE-1】重组蛋白信息

BACE-1产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
BA1-H5220
Human
Human BACE-1 Protein, His Tag
BA1-H5261
Human
Human-BACE1-Protein-N-Fc-Tag
BA1-H5213
Human
Human BACE1 Protein,Tag Free

BACE-1 分子别名

BACE1,ASP2,BACE,FLJ90568,HSPC104,KIAA1149,Memapsin-2

BACE-1 分子背景

Beta-secretase 1 (BACE1) is also known as beta-site APP cleaving enzyme 1 (beta-site amyloid precursor protein cleaving enzyme 1), memapsin-2 (membrane-associated aspartic protease 2), and aspartyl protease 2 (ASP2), β-Secretase , and is a member of the peptidase A1 protein family, BACE1 is a type I  integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. BACE1 is an aspartic-acid protease important in the pathogenesis of Alzheimer's disease, and in the formation of myelin sheaths in peripheral nerve cells. The transmembrane protein contains two active site aspartate residues in its extracellular protein domain and may function as a dimer. This protease is responsible for the proteolytic processing of the amyloid precursor protein (APP). Generation of the 40 or 42 amino acid-long amyloid-β peptides that aggregate in the brain of Alzheimer's patients requires two sequential cleavages of the APP. Extracellular cleavage of APP by BACE creates a soluble extracellular fragment and a cell membrane-bound fragment referred to as C99. The elevation of BACE1 levels can be induced by amyloid plaques surrounding neurons at early stages of pathology before neuron death occurs, and may drive a positive-feedback loop in AD.

BACE-1 参考文献

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