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Human CD52 Protein, Fc Tag

分子别名(Synonym)

CDW52,HE5,CD52,CAMPATH-1 antigen

表达区间及表达系统(Source)

Human CD52, Fc Tag (CD2-H525a) is expressed from human 293 cells (HEK293). It contains AA Gly 25 - Ser 36 (Accession # P31358-1).

Predicted N-terminus: Gly 25

蛋白结构(Molecular Characterization)

Online(Gly 25  - Ser 36) P31358-1

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 27.9 kDa. The protein migrates as 38-43 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Human CD52, Fc Tag (Cat. No. CD2-H525a) SDS-PAGE gel

Human CD52, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

 

活性(Bioactivity)-ELISA

Biotinylated Human ELISA

Immobilized Human CD52, Fc Tag (Cat. No. CD2-H525a) at 10 μg/mL (100 μL/well) can bind Alemtuzumab with a linear range of 0.313-10 μg/mL (QC tested).

Protocol

背景(Background)

CAMPATH-1 antigen, also known as cluster of differentiation 52 (CD52), is a glycoprotein that in humans is encoded by the CD52 gene.It is widely expressed on the cell surface of immune cells, such as mature lymphocytes, natural killer cells (NK), eosinophils, neutrophils, monocytes/macrophages, and dendritic cells (DCs).ligation of cell surface CD52 molecules may offer costimulatory signals for T-cell activation and proliferation.

 

前沿进展

 
货号/价格

CD2-H525a-100ug / ¥3000

CD2-H525a-1mg / ¥19800

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CD52靶点信息
英文全称:CAMPATH-1 antigen
中文全称:CAMPATH-1抗原
种类:Homo sapiens
上市药物数量:1详情
临床药物数量:6详情
最高研发阶段:批准上市
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