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 >  其他蛋白>Siglec-E >SGE-M52A3

Mouse Siglec-E Protein, Mouse IgG1 Fc (D142A) Tag (MALS verified)

分子别名(Synonym)

Siglec-E,Siglec-12,Siglec-5,Siglec-L1,Siglece,Sialic acid-binding Ig-like lectin 12,MIS

表达区间及表达系统(Source)

Mouse Siglec-E Protein, Mouse IgG1 Fc (D142A) Tag (SGE-M52A3) is expressed from human 293 cells (HEK293). It contains AA Pro 2 - Cys 333 (Accession # Q91Y57-1 ).

Predicted N-terminus: Pro 2

Request for sequence

蛋白结构(Molecular Characterization)

Siglec-E Structure

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 63.5 kDa. The protein migrates as 90-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 0.1 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Siglec-E SDS-PAGE

Mouse Siglec-E Protein, Mouse IgG1 Fc (D142A) Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS

Siglec-E SEC-MALS

The purity of Mouse Siglec-E Protein, Mouse IgG1 Fc (D142A) Tag (Cat. No. SGE-M52A3) is more than 85% and the molecular weight of this protein is around 155-185 kDa verified by SEC-MALS.

Report

背景(Background)

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

 

 
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