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Human Coagulation Factor II / Thrombin Protein, His Tag

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分子别名(Synonym)

thrombin,Coagulation factor II

表达区间及表达系统(Source)

Human Coagulation Factor II, His Tag (THN-H52H0) is expressed from human 293 cells (HEK293). It contains AA Gln 25 - Glu 622 (Accession # AAH51332).

Predicted N-terminus: Gln 25

蛋白结构(Molecular Characterization)

Online-Res(Gln 25 - Glu 622) AAH51332

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 69.5 kDa.

内毒素(Endotoxin)

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

背景(Background)

Prothrombin is also known as coagulation factor II (F2),which can be cleaved into the following 4 chains: activation peptide fragment 1, activation peptide fragment 2, thrombin light chain and thrombin heavy chain. Coagulation factor II (F2) is able to form a heterodimer with SERPINA5. The mutations of F2 gene can result in a very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. Furthermore, thrombin converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Coagulation factor II (F2) can also play an important role in blood homeostasis, inflammation and wound healing.

 

前沿进展

 
货号/价格

THN-H52H0-50ug / ¥3500

THN-H52H0-500ug / ¥12000

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Coagulation Factor II靶点信息
英文全称:Prothrombin
中文全称:凝血酶原
种类:Homo sapiens
上市药物数量:41详情
临床药物数量:63详情
最高研发阶段:批准上市
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