Human Truncated Vitronectin / VTN-N Protein, Research Grade
academia only

  • This product is specifically for academia customers.
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价格
Qty.
VIN-H5118-100ug
¥200.00
VIN-H5118-1mg
¥1050.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    VTN, V75, VN, Vitronectin, S-protein, Serum-spreading factor

  • 表达区间及表达系统(Source)

    Human Truncated Vitronectin Protein, Research Grade (VIN-H5118) is expressed from E. coli cells. It contains AA Val 62 - Leu 478 (Accession # P04004).

    Predicted N-terminus: Met

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    Vitronectin Structure

    This protein carries no "tag".

    The protein has a calculated MW of 47.6 kDa. The protein migrates as 46 kDa±3 kDa and 53 kDa±3 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

  • 内毒素(Endotoxin)

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • 纯度(Purity)

    >95% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Supplied as 0.2 μm filtered solution in PBS, 0.15 M Arginine, 0.5 mM EDTA, 250 mM N-Acetyl-L-cysteine, pH7.4 with glycerol as protectant.

    Contact us for customized product form or formulation.

  • 运输(Shipping)

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • 存储(Storage)

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 years under sterile conditions.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程
  • 质量说明(Quality Description)

    ACRO's Research-grade products are suitable for a wide range of cell culture applications, particularly for research use in academic institutions. These products are sterilized by filtration before lyophilization. Typical specifications include endotoxin levels of <0.01 EU/μg and purities >95%. Biological activity is calibrated against WHO/NIBSC standards when available.
    ACRO's Premium-grade (Pre-GMP) products are characterized by their high quality and enhanced safety profiles, making them ideal for early-stage discovery and manufacturing processes in cell therapy companies. A key advantage is their seamless transition to corresponding GMP-grade versions. Biological activity is calibrated against WHO/NIBSC standards when available. Typical specifications include endotoxin levels of <0.01 EU/μg and purities >95%. In addition, rigorous testing is conducted to ensure the absence of mycoplasma, HCD, and HCP, thereby guaranteeing product safety.

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数据展示

  • 电泳(SDS-PAGE)

    Vitronectin SDS-PAGE

    Human Truncated Vitronectin Protein, Research Grade on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • 活性(Bioactivity)-SPR

     Vitronectin SPR

    Human ITGAV&ITGB3 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT3-H52E3) immobilized on CM5 Chip can bind Human Truncated Vitronectin Protein, Research Grade (Cat. No. VIN-H5118) with an affinity constant of 19.2 nM as determined in a SPR assay (Biacore T200) (QC tested).

    Protocol

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背景介绍

Vitronectin is also known as S-protein, VN, VTN, V75. Vitronectin, a multifunctional glycoprotein, is involved in coagulation, inhibition of the formation of the membrane attack complex (MAC), cell adhesion and migration, wound healing, and tissue remodeling. The primary cellular source of vitronectin is hepatocytes. Blocking of Hic(a member of the pneumococcal surface protein C (PspC) family) by specific antiserum or genetic deletion significantly reduced pneumococcal binding to soluble and immobilised vitronectin and to Factor H, respectively. In addition, Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.

前沿进展

 
药物研发进展
  • 英文全称:

    Vitronectin

  • 中文全称:

    玻连蛋白

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    0 详情

  • 最高研发阶段:

    临床前

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