Human uPAR / PLAUR (209-303) Protein, His Tag (MALS verified)

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UPR-H52H6-100ug
¥3675.00
UPR-H52H6-1mg (500ug X 2)
¥24255.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    uPAR, PLAUR, CD87, MO3

  • 表达区间及表达系统(Source)

    Human uPAR (209-303), His Tag (UPR-H52H6) is expressed from human 293 cells (HEK293). It contains AA Leu 209 - Arg 303 (Accession # Q03405-1).

    Predicted N-terminus: Leu 209

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    uPAR Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 12.3 kDa. The protein migrates as 23-28 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 内毒素(Endotoxin)

    Less than 0.1 EU per μg by the LAL method / rFC method.

  • 纯度(Purity)

    >90% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    uPAR SDS-PAGE

    Human uPAR (209-303), His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • SEC-MALS

    uPAR SEC-MALS

    The purity of Human uPAR (209-303), His Tag (Cat. No. UPR-H52H6) is more than 95% and the molecular weight of this protein is around 18-28 kDa verified by SEC-MALS.

    Report

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背景介绍

Urokinase plasminogen activator surface receptor (U-PAR) is also known as PLAUR, Monocyte activation antigen Mo3, CD antigen CD87. PLAUR contains three UPAR/Ly6 domains. U-PAR is expressed in neurons of the rolandic area of the brain (at protein level) and is also expressed in the brain. PLAUR / CD87 interacts with MRC2, SRPX2 and SORL1. PLAUR / UPAR acts as a receptor for urokinase plasminogen activator and plays a role in localizing and promoting plasmin formation. U-PAR mediates the proteolysis-independent signal transduction activation effects of U-PA.

前沿进展

 
药物研发进展
  • 英文全称:

    Urokinase plasminogen activator surface receptor

  • 中文全称:

    尿激酶型纤溶酶原激活物表面受体

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    7 详情

  • 最高研发阶段:

    临床三期

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