Human Tyk2 Protein, His Tag

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货号-规格
价格
Qty.
TY2-H5548-100ug
¥3150.00
TY2-H5548-1mg
¥20790.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    Tyk2,tyrosine kinase 2

  • 表达区间及表达系统(Source)

    Human Tyk2 Protein, His Tag (TY2-H5548) is expressed from Baculovirus-Insect cells. It contains AA Asn 575 - Leu 869 (Accession # P29597-1).

    Predicted N-terminus: His

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    Tyk2 Structure

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 35.2 kDa. The protein migrates as 35 kDa under reducing (R) condition (SDS-PAGE).

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 纯度(Purity)

    >90% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Supplied as 0.2 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with glycerol as protectant.

    Contact us for customized product form or formulation.

  • 运输(Shipping)

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • 存储(Storage)

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 电泳(SDS-PAGE)

    Tyk2 SDS-PAGE

    Human Tyk2 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

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背景介绍

Tyk2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3). It has been implicated in IFN-α, IL-6, IL-10 and IL-12 signaling. Tyk2 functions primarily in IL-12 and type I-IFN signaling. Tyk2 deficiency has more dramatic effects in human cells than in mouse cells. However, in addition to IFN-α and -β and IL-12 signaling, Tyk2 has major effects on the transduction of IL-23, IL-10, and IL-6 signals. Recently, it has been recognized that IL-12 and IL-23 share ligand and receptor subunits that activate Tyk2. Tyk2 is activated by IL-10, and its deficiency affects the ability to generate and respond to IL-10.

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