Biotinylated Rhesus macaque TROP-2 / TACSTD2 Protein, Fc,Avitag™ (MALS verified)

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TR2-R82F6-25ug
¥3865.00
TR2-R82F6-200ug
¥15225.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    TACSTD2,GA733-1,M1S1,TROP2

  • 表达区间及表达系统(Source)

    Biotinylated Rhesus macaque TROP-2 Protein, Fc,Avitag (TR2-R82F6) is expressed from human 293 cells (HEK293). It contains AA Gln 31 - Thr 274 (Accession # XP_001114599.1).

    Predicted N-terminus: Gln 31

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    TROP-2 Structure

    This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag™).

    The protein has a calculated MW of 55.6 kDa. The protein migrates as 63-80 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 标记(Labeling)

    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

  • 蛋白标记度(Protein Ratio)

    Passed as determined by the HABA assay / binding ELISA.

  • 纯度(Purity)

    >90% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM Nacl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    TROP-2 SDS-PAGE

    Biotinylated Rhesus macaque TROP-2 Protein, Fc,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    TROP-2 SEC-MALS

    The purity of Biotinylated Rhesus macaque TROP-2 Protein, Fc,Avitag (Cat. No. TR2-R82F6) is more than 85% and the molecular weight of this protein is around 118-138 kDa verified by SEC-MALS.

    Report
  • 活性(Bioactivity)-ELISA

     TROP-2 ELISA

    Immobilized Mouse Monoclonal Antibody Against Human TROP-2 Protein,Mouse IgG1 at 1 μg/mL (100 μL/well) can bind Biotinylated Rhesus macaque TROP-2 Protein, Fc,Avitag (Cat. No. TR2-R82F6) with a linear range of 0.1-8 ng/mL (QC tested).

    Protocol
  •  TROP-2 ELISA

    Immobilized Biotinylated Rhesus macaque TROP-2 Protein, Fc,Avitag (Cat. No. TR2-R82F6) at 1 μg/mL (100 μL/well on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Mouse Monoclonal Antibody Against Human TROP-2 Protein,Mouse IgG1 with a linear range of 0.1-8 ng/mL (Routinely tested).

    Protocol

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背景介绍

TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.

前沿进展

 
药物研发进展
  • 英文全称:

    Tumor-associated calcium signal transducer 2

  • 中文全称:

    肿瘤相关钙信号传感器2

  • 种类:

  • 上市药物数量:

    3 详情

  • 临床药物数量:

    25 详情

  • 最高研发阶段:

    批准上市

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