Human Transthyretin / Prealbumin Protein, His Tag

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TTR-H5223-100ug
¥2890.00
TTR-H5223-1mg (500ug X 2)
¥17325.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    Transthyretin,TTR,Prealbumin,TBPA,ATTR,PALB,CTS,CTS1,HsT2651

  • 表达区间及表达系统(Source)

    Human Transthyretin, His Tag (TTR-H5223) is expressed from human 293 cells (HEK293). It contains AA Gly 21 - Glu 147 (Accession # NP_000362).

    Predicted N-terminus: Gly 21

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    Transthyretin Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 14.9 kDa. The protein migrates as 17 kDa and 33 kDa under reducing (R) condition (SDS-PAGE) due to the monomer and dimer respectively.

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 纯度(Purity)

    >95% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    Transthyretin SDS-PAGE

    Human Transthyretin, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

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背景介绍

Transthyretin (TTR) is also known as Prealbumin, ATTR, TBPA, PALB, which belongs to the transthyretin family. Transthyretin / TTR is a serum and cerebrospinal fluid carrier of the thyroid hormone thyroxine (T4) and retinol-binding protein bound to retinol. In cerebrospinal fluid TTR is the primary carrier of T4. TTR also acts as a carrier of retinol (vitamin A) through its association with retinol-binding protein (RBP) in the blood and the CSF. Less than 1% of TTR's T4 binding sites are occupied in blood. TTR misfolding and aggregation is known to be associated with the amyloid diseases.

前沿进展

 
药物研发进展
  • 英文全称:

    Transthyretin

  • 中文全称:

    转甲状腺素蛋白

  • 种类:

  • 上市药物数量:

    7 详情

  • 临床药物数量:

    6 详情

  • 最高研发阶段:

    批准上市

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