Human TM4SF1 Full Length Protein (VLP)

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货号-规格
价格
Qty.
TM1-H52P3-20ug
¥5250.00
TM1-H52P3-100ug
¥10500.00
TM1-H52P3-500ug (250ug X 2)
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合计0件 产品金额¥ 0

产品详情

  • 应用说明(Application)

    1. Immunization
    2. FACS
    3. Elisa
  • 分子别名(Synonym)

    TM4SF1

  • 表达区间及表达系统(Source)

    Human TM4SF1 Full Length Protein (VLP) (TM1-H52P3) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Cys 202 (Accession # P30408).

    Predicted N-terminus: Met 1

  • 蛋白结构(Molecular Characterization)

    1. Structure

      Virus-like particles (VLPs) are protein particles that mimic the shape of viruses but lack a viral genome, and incorporating transmembrane proteins on the external surface.

    2. Synthesis Process

      Virus-like particles (VLPs) are non-infectious structures that mimic the shape of viruses but lack a viral genome. During VLP production in cells systems, VLPs self-assemble into 100-200 nm protein particles, and incorporate transmembrane proteins into a VLP-MP complex, resulting in presentation of the protein on the external surface of the VLP. Their repetitive, multivalent surface display and strong immunogenicity, making them an excellent candidate for immunization.

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 制剂(Formulation)

    The VLPs are highly immunogenic, so the immunization strategy should be optimized (antigen dose, regimen and adjuvant).

    Supplied as 0.2 μm filtered solution in PBS, Arginine, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 运输(Shipping)

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • 存储(Storage)

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 12 months under sterile conditions.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程
  • *The isotype control of empty/mock VLP (Cat. No. VLP-N5213) is sold separately and not included in protein, you can follow the link for product information.

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数据展示

  • 活性(Bioactivity)-ELISA

     TM4SF1 ELISA

    Immobilized Human TM4SF1 Full Length Protein (VLP) (Cat. No. TM1-H52P3) at 5 μg/mL (100 μL/well) can bind Anti-TM4SF1 Antibody with a linear range of 0.06-4 ng/mL (QC tested).

    Protocol
  • 均一性(Identity)-DLS

     TM4SF1 DLS

    The mean peak Radius of VLP is 60-80 nm with more than 95% intensity as determined by dynamic light scattering (DLS).

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背景介绍

A tetraspanin protein overexpressed on tumor vasculature endothelium and cancer cells, promoting angiogenesis and metastasis. TM4SF1 organizes signaling complexes at the cell surface. It is an emerging target for antibody-drug conjugates and anti-angiogenic therapies, particularly in solid tumors reliant on pathological vessel formation.

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