选择语言
免费注册
关注公众号
微信客服
收藏产品

Rabbit TL1A / TNFSF15 Protein, His Tag (MALS verified)

COADS MS
DS
用户评价
货号-规格
价格
Qty.
TLA-R5243-100ug
¥3675.00
TLA-R5243-1mg
¥24255.00
合计0件 产品金额¥ 0
新品建议
增项建议

产品详情

  • 分子别名（Synonym）

    TL1A, VEGI, TNFSF15

  • 表达区间及表达系统（Source）

    Rabbit TL1A / TNFSF15 Protein, His Tag (TLA-R5243) is expressed from human 293 cells (HEK293). It contains AA Leu 162 - Leu 340 (Accession # G1T1T1).

    Request for sequence

  • 蛋白结构（Molecular Characterization）

    TL1A Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 22.4 kDa. The protein migrates as 30 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

    The protein is designed as a trimer.

  • 内毒素（Endotoxin）

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 纯度（Purity）

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • 制剂（Formulation）

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法（Reconstitution）

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储（Storage）

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

推荐产品

数据展示

  • 电泳（SDS-PAGE）

    TL1A SDS-PAGE

    Rabbit TL1A / TNFSF15 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    TL1A SEC-MALS

    The purity of Rabbit TL1A / TNFSF15 Protein, His Tag (Cat. No. TLA-R5243) is more than 90% and the molecular weight of this protein is around 90-110 kDa verified by SEC-MALS.

    Report

用户评价
发表评论

背景介绍

TL1A, or Tumor Necrosis Factor Superfamily Member 15 (TNFSF15), also known as TL1 or VEGI, is a type II transmembrane protein belonging to the TNF ligand superfamily. It functions as a key regulator of both innate and adaptive immune responses. While expressed primarily in glandular, squamous, and specialized epithelial cells, TL1A is also found in immune cells such as macrophages and dendritic cells. Its C-terminal extracellular domain contains a TNF homology domain (THD), forming a homotrimeric structure. The functional receptor for TL1A is Death Receptor 3 (DR3, TNFRSF25), a type I transmembrane protein. TL1A's signaling pathway is modulated by decoy receptor 3 (DcR3), which competes with DR3 for ligand binding. Upon binding to DR3, TL1A can activate pro-inflammatory signaling cascades (NF-κB, MAPK, PI3K) or, alternatively, trigger TRADD dissociation and FADD-mediated apoptosis via caspase-8 and caspase-3 activation. This dual signaling capacity makes TL1A a target of interest for the treatment of inflammatory bowel disease (IBD), allergic diseases, and autoimmune conditions.

前沿进展

 
药物研发进展
  • 英文全称：

    Tumor necrosis factor superfamily member 15

  • 中文全称：

    肿瘤坏死因子超家族成员15

  • 种类：

  • 上市药物数量：

    0 详情

  • 临床药物数量：

    11 详情

  • 最高研发阶段：

    临床三期

联系我们
项目合作
查看更多项目
实验案例分析
查看更多案例分析
  • 产品基础信息
  • 产品详情
  • 推荐产品
  • 数据展示
  • 用户评价
  • 背景介绍