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分子别名（Synonym）
Spike,S1 protein,Spike glycoprotein Subunit1,S glycoprotein Subunit1,Spike protein S1
表达区间及表达系统（Source）
HCoV-HKU1(isolate N5) S1 protein, His Tag (SIN-V52H6) is expressed from human 293 cells (HEK293). It contains AA Ala 13 - Arg 756 (Accession # Q0ZME7-1).
Predicted N-terminus: Ala 13
Request for sequence蛋白结构（Molecular Characterization）
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 85.7 kDa. The protein migrates as 110-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素（Endotoxin）
Less than 1.0 EU per μg by the LAL method / rFC method.
纯度（Purity）
>90% as determined by SDS-PAGE.
制剂（Formulation）
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
质量管理控制体系（QMS）
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数据展示
电泳（SDS-PAGE）
HCoV-HKU1(isolate N5) S1 protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.
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背景介绍
HCoV-HKU1 is an enveloped virus, meaning its genetic material is contained within a lipid membrane surrounded by structural proteins. This envelope is studded with glycoproteins, including the Spike Protein (S Protein), which plays a critical role in virus attachment and entry into host cells. The S Protein is a type I transmembrane protein that protrudes from the virus surface, serving as a bridge between the virus and its host cell receptor. Once the S Protein binds to its cognate receptor on the host cell surface, it triggers a series of events leading to the fusion of the viral and cellular membranes, allowing the release of the virus's genetic material into the host cell cytoplasm.
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