Bat coronavirus Anlong103 Spike Trimer Protein (R645A, K946P, V947P), His Tag (MALS verified)

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SPN-S522f-100ug
¥4725.00
SPN-S522f-1mg (500ug X 2)
¥29400.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    Spike, S protein, Spike glycoprotein, S glycoprotein

  • 表达区间及表达系统(Source)

    Bat coronavirus Anlong103 Spike Trimer Protein, His Tag (SPN-S522f) is expressed from human 293 cells (HEK293). It contains AA Asp 14 - Pro 1173 (Accession # A0A1W5YKT9 (R645A, K946P, V947P)).

    Predicted N-terminus: Asp 14

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    Spike protein Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 133.5 kDa. The protein migrates as >160 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

    The protein is designed as a trimer.

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 纯度(Purity)

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in 0.1 M Sodium citrate, pH5.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    Spike protein SDS-PAGE

    Bat coronavirus Anlong103 Spike Trimer Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    Spike protein SEC-MALS

    The purity of Bat coronavirus Anlong103 Spike Trimer Protein, His Tag (Cat. No. SPN-S522f) is more than 90% and the molecular weight of this protein is around 510-560 kDa verified by SEC-MALS.

    Report

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背景介绍

The spike protein of bat coronavirus Anlong103, a SARS-CoV-2–related sarbecovirus identified in bats from China’s Guizhou province, mediates viral entry by facilitating receptor attachment and membrane fusion. While closely related to other bat coronaviruses, Anlong103’s spike shows distinct structural features that may limit human ACE2 binding, yet retains conserved antigenic sites. These characteristics make it valuable for studying cross-species transmission potential and coronavirus evolution in wildlife reservoirs.

前沿进展

 
药物研发进展
  • 英文全称:

    Coronavirus spike glycoprotein

  • 中文全称:

    冠状病毒刺突糖蛋白

  • 种类:

  • 上市药物数量:

    10 详情

  • 临床药物数量:

    72 详情

  • 最高研发阶段:

    批准上市

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