Rat Sortilin Protein, His Tag (MALS verified)

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SON-R52H3-100ug
¥4250.00
SON-R52H3-1mg
¥29040.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    Sortilin, SORT1, 100 kDa NT receptor, Glycoprotein 95, Gp95, Gp95LDLCQ6, Neurotensin receptor 3, NT3NTR3, Ntr3, sortilin 1,

  • 表达区间及表达系统(Source)

    Rat Sortilin Protein, His Tag (SON-R52H3) is expressed from human 293 cells (HEK293). It contains AA Gly 76 - Ser 753 (Accession # O54861).

    Predicted N-terminus: Gly 76

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    Sortilin Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 77.4 kDa. The protein migrates as 90-120 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 纯度(Purity)

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    Sortilin SDS-PAGE

    Rat Sortilin Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    Sortilin SEC-MALS

    The purity of Rat Sortilin Protein, His Tag (Cat. No. SON-R52H3) is more than 90% and the molecular weight of this protein is around 80-110 kDa verified by SEC-MALS.

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背景介绍

Sortilin is a multifunctional type-I transmembrane protein belonging to the Vps10p-domain receptor family (Vps10p-Domain Receptors, Vps10p-DRs). Sortilin plays a central role in cellular protein sorting, signal transduction, and metabolism. Its dysfunction is closely related to neurodegenerative diseases, metabolic syndrome, and cancer, and it is a potential therapeutic target for diseases.

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药物研发进展
  • 英文全称:

    Sortilin

  • 中文全称:

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    2 详情

  • 最高研发阶段:

    临床三期

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