Human SMO Protein, His,Flag Tag (Detergent)

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SMO-H52D3-20ug
¥7350.00
SMO-H52D3-100ug
¥27300.00
SMO-H52D3-500ug
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产品详情

  • 分子别名(Synonym)

    SMO,smoothened, frizzled class receptor,CRJS, FZD11, Gx, PHLS, SMOH

  • 表达区间及表达系统(Source)

    Human SMO Protein, His,Flag Tag (SMO-H52D3) is expressed from human 293 cells (HEK293). It contains AA Arg 28 - Gln 555 (Accession # Q99835-1).

    Predicted N-terminus: Arg 28

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    SMO Structure

    This protein carries a polyhistidine tag at the C-terminus, followed by a Flag tag. The protein has a calculated MW of 77.0 kDa.

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 纯度(Purity)

    >90% as determined by SDS-PAGE.

  • 制剂(Formulation)

    This product is not suitable for cell based experiments due to cytotoxicity of DDM.
    DDM and CHS are INDISPENSABLE to keep membrane protein soluble and active, under no circumstances should you remove DDM and CHS.
    DDM/CHS buffer (DC-11) is sold separately and not included in protein, and please contact us if you need the buffer.
    If glycerol is not compatible with your application, remove glycerol just before the immediate experiment, and NEVER store glycerol-free protein solution.

    Supplied as 0.2 μm filtered solution in 50 mM HEPES, 150 mM NaCl, DDM, CHS, pH7.5 with glycerol as protectant.

    Contact us for customized product form or formulation.

  • 运输(Shipping)

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • 存储(Storage)

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程
  • *The DDM/CHS buffer (Cat. No. DC-11) is sold separately and not included in protein, you can follow this link for product information.

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  • 活性(Bioactivity)-ELISA

     SMO ELISA

    Immobilized Human SMO Protein, His,Flag Tag (Cat. No. SMO-H52D3) at 1 μg/mL (100 μL/well) can bind Anti-SMO antibody with a linear range of 1-63 ng/mL (QC tested).

    Protocol

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背景介绍

The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex.

前沿进展

 
药物研发进展
  • 英文全称:

    Smoothened receptor

  • 中文全称:

    SMO受体

  • 种类:

  • 上市药物数量:

    3 详情

  • 临床药物数量:

    5 详情

  • 最高研发阶段:

    批准上市

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