Human SMN1 Protein, His Tag

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价格
Qty.
SM1-H5145-100ug
¥3150.00
SM1-H5145-1mg (500ug X 2)
¥20790.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    Survival Motor Neuron 1, SMN1

  • 表达区间及表达系统(Source)

    Human SMN1, His Tag (SM1-H5145) is expressed from E. coli cells. It contains AA Ala 2 - Asn 294 (Accession # Q16637-1).

    Predicted N-terminus: Met

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    SMN1 Structure

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 33.7 kDa. The protein migrates as 36-40 kDa and 69 kDa under reducing (R) condition (SDS-PAGE).

  • 纯度(Purity)

    >90% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, 0.5 M Arginine, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    SMN1 SDS-PAGE

    Human SMN1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • 活性(Bioactivity)-ELISA

     SMN1 ELISA

    Immobilized Human SMN1, His Tag (Cat. No. SM1-H5145) at 1 μg/mL (100 μL/well) can bind Anti-SMN1 antibody with a linear range of 0.2-8 ng/mL (QC tested).

    Protocol

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背景介绍

SMN1 is produced chiefly by the SMN1 gene, located on the telomeric portion of chromosome 5q. SMN1 protein is one of a group of proteins called the SMN complex, which is important for the maintenance of specialized nerve cells called motor neurons. In cells, the SMN complex plays an important role in processing mRNA. The SMN complex helps to assemble the cellular machinery needed to process pre-mRNA. The SMN complex is also important for the development of specialized outgrowths from nerve cells called dendrites and axons. Deletion or mutation of the SMN1 gene results in a reduced level of full-length SMN protein and manifests as a range of neuromuscular phenotypes in humans as the disease spinal muscular atrophy (SMA).

前沿进展

 
药物研发进展
  • 英文全称:

    Survival motor neuron protein

  • 中文全称:

    运动神经元存活蛋白

  • 种类:

  • 上市药物数量:

    3 详情

  • 临床药物数量:

    7 详情

  • 最高研发阶段:

    批准上市

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