Human PTP4A3 Protein, His Tag (MALS verified)

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PT3-H5143-50ug
¥4500.00
PT3-H5143-500ug
¥26000.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    PTP4A3

  • 表达区间及表达系统(Source)

    Human PTP4A3 Protein, His Tag (PT3-H5143) is expressed from E. coli cells. It contains AA Ala 2 - Cys 170 (Accession # O75365).

    Predicted N-terminus: Met

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    PTP4A3 Structure

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 21.1 kDa. The protein migrates as 23-25 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

  • 纯度(Purity)

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, 0.2 M Arginine, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    PTP4A3 SDS-PAGE

    Human PTP4A3 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    PTP4A3 SEC-MALS

    The purity of Human PTP4A3 Protein, His Tag (Cat. No. PT3-H5143) is more than 90% and the molecular weight of this protein is around 20-35 kDa verified by SEC-MALS.

    Report

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背景介绍

​​PTP4A3 (Protein Tyrosine Phosphatase 4A3)​​ is an oncogenic phosphatase that promotes tumor metastasis by enhancing cell migration, invasion, and survival. It is overexpressed in multiple cancers (e.g., breast, ovarian, colorectal) and correlates with poor prognosis. PTP4A3 activates Rho GTPases and downstream pathways (ROCK/LIMK/cofilin) to remodel the actin cytoskeleton, facilitating cancer cell dissemination. Its dual cysteine-based catalytic domain dephosphorylates key signaling proteins, driving aggressive phenotypes. Targeting PTP4A3 offers therapeutic potential for inhibiting metastasis.

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