Human PCSK9 Protein, C-terminal domain truncated, His Tag

分子别名（Synonym）

PCSK9, FH3, HCHOLA3, LDLCQ1, NARC1, PC9

表达区间及表达系统（Source）

Human PCSK9 Protein, C-terminal domain truncated, His Tag (PC9-H52H7) is expressed from human 293 cells (HEK293). It contains AA Gln 31 -His 449 (Accession # Q8NBP7-1).

Predicted N-terminus: Gln 31 & Ser 153

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 13.8 kDa & 33.5 kDa. The protein migrates as 15 kDa and 33 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation. This protein variant lacks the C-terminal domain (CRD), which is essential for its LDLR binding and degradation functions.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method / rFC method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;
2. -70°C for 3 months under sterile conditions after reconstitution.

质量管理控制体系（QMS）

1. 质量管理体系（ISO, GMP）
2. 质量优势
3. 质控流程