Human NKp46 / NCR1 / CD335 Protein, Fc Tag

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NC1-H5259-100ug
¥4045.00
NC1-H5259-1mg
¥26670.00
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产品详情

  • 分子别名(Synonym)

    NCR1,LY94,CD335,NK-p46,hNKp46

  • 表达区间及表达系统(Source)

    Human NKp46 Protein, Fc Tag (NC1-H5259) is expressed from human 293 cells (HEK293). It contains AA His 129 - Thr 211 (Accession # O76036-1).

    Predicted N-terminus: His 129

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    NKp46 Structure

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 35.8 kDa . The protein migrates as 40-43 kDa, 53 kDa and 60-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 纯度(Purity)

    >85% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    NKp46 SDS-PAGE

    Human NKp46 Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 85% (With Star Ribbon Pre-stained Protein Marker).

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背景介绍

Natural cytotoxicity triggering receptor 1 (NCR1) is also known as Natural killer cell p46-related protein (NK-p46), Lymphocyte antigen 94 homolog (LY94), CD antigen CD335, which belongs to the natural cytotoxicity receptor (NCR) family. NCR1 contains two Ig-like (immunoglobulin-like) domains. NCR1 interacts with CD247 and FCER1G. NCR1 / CD335 may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

前沿进展

 
药物研发进展
  • 英文全称:

    Natural cytotoxicity triggering receptor 1

  • 中文全称:

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    4 详情

  • 最高研发阶段:

    临床二期

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