APC-Labeled Human Mucin-1 / MUC-1 Protein, His Tag (Site-specific conjugation)

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MU1-HA2H8-25tests
¥3675.00
MU1-HA2H8-200tests
¥22880.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    Mucin 1,MUC1,CD227,EMA,H23AG,KL-6,MAM6,MUC-1,SEC,MUC-1,X,MUC1,ZD,PEM,PEMT,PUM,CA15-3,Episialin

  • 表达区间及表达系统(Source)

    APC-Labeled Human Mucin-1 Protein, His Tag (MU1-HA2H8) is produced via conjugation of APC to Human Mucin-1 Protein, His Tag with a new generation site-specific technology under optimal conditions with a proprietary technology. Human Mucin-1 Protein, His Tag is expressed from human 293 cells (HEK293). It contains AA Ser 890 - Gly 1158 (Accession # P15941-1).

    Predicted N-terminus: Ser 890 & Ser 1098

    Request for sequence

  • 蛋白结构(Molecular Characterization)

    Mucin-1 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 21.3 kDa & 10.2 kDa.

  • 偶联(Conjugate)

    APC

    Excitation Wavelength: 640 nm

    Emission Wavelength: 661 nm

  • 应用说明(Application)

    Please note that this product is NOT compatible to streptavidin detection system.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, 0.5% BSA, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 活性(Bioactivity)-FACS

     Mucin-1 FACS

    5e5 of anti-Mucin-1 (F1C) CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of APC-Labeled Human Mucin-1 Protein, His Tag (Cat. No. MU1-HA2H8) and negative control protein respectively. APC signal was used to evaluate the binding activity (QC tested).

    Protocol

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背景介绍

Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction. MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites. Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization. Probably plays a role in maintaining homeostasis on mucosal surfaces.

前沿进展

 
药物研发进展
  • 英文全称:

    Mucin-1

  • 中文全称:

    黏蛋白-1

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    22 详情

  • 最高研发阶段:

    临床二期

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