Biotinylated Human LILRB1 / CD85j / ILT2 Protein, His,Avitag™ (MALS verified)

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CDJ-H82E8-200ug
¥15215.00
CDJ-H82E8-25ug
¥3865.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    CD85J,LILRB1,CD85,ILT2,LIR1,MIR7

  • 表达区间及表达系统(Source)

    Biotinylated Human LILRB1 Protein, His,Avitag (CDJ-H82E8) is expressed from human 293 cells (HEK293). It contains AA Ala 23 - Thr 431 (Accession # Q8NHL6-1).

    Predicted N-terminus: Ala 23

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    LILRB1 Structure

    This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™).

    The protein has a calculated MW of 48.2 kDa. The protein migrates as 52-64 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 标记(Labeling)

    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

  • 蛋白标记度(Protein Ratio)

    Passed as determined by the HABA assay / binding ELISA.

  • 纯度(Purity)

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    LILRB1 SDS-PAGE

    Biotinylated Human LILRB1 Protein, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    LILRB1 SEC-MALS

    The purity of Biotinylated Human LILRB1 Protein, His,Avitag (Cat. No. CDJ-H82E8) is more than 95% and the molecular weight of this protein is around 50-65 kDa verified by SEC-MALS.

    Report

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背景介绍

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

前沿进展

 
药物研发进展
  • 英文全称:

    Leukocyte immunoglobulin-like receptor B1

  • 中文全称:

    白细胞免疫球蛋白样受体B1

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    7 详情

  • 最高研发阶段:

    临床二期

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