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Human JAK1 Protein, His Tag

COADS MS
DS
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货号-规格
价格
Qty.
JA1-H5547-50ug
¥3675.00
JA1-H5547-1mg
¥27300.00
合计0件 产品金额¥ 0
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产品详情

  • 分子别名（Synonym）

    JAK1,JAK-1,JAK1A,JAK1B,Jak1

  • 表达区间及表达系统（Source）

    Human JAK1, His Tag (JA1-H5547) is expressed from Baculovirus-Insect cells. It contains AA Ala 561 - Asn 852 (Accession # P23458-1).

    Predicted N-terminus: Met

    Request for sequence

  • 蛋白结构（Molecular Characterization）

    JAK1 Structure

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 35.7 kDa. The protein migrates as 30-33 kDa under reducing (R) condition (SDS-PAGE).

  • 内毒素（Endotoxin）

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 纯度（Purity）

    >95% as determined by SDS-PAGE.

  • 制剂（Formulation）

    Supplied as 0.2 μm filtered solution in 50 mM Tris, 500 mM NaCl, pH8.0 with glycerol as protectant.

    Contact us for customized product form or formulation.

  • 运输（Shipping）

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • 存储（Storage）

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳（SDS-PAGE）

    JAK1 SDS-PAGE

    Human JAK1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

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背景介绍

JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body

前沿进展

 
药物研发进展
  • 英文全称：

    Tyrosine-protein kinase JAK1

  • 中文全称：

    酪氨酸蛋白激酶JAK1

  • 种类：

  • 上市药物数量：

    10 详情

  • 临床药物数量：

    41 详情

  • 最高研发阶段：

    批准上市

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