Human IRAK4 Protein, His Tag

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IR4-H5546-100ug
¥3990.00
IR4-H5546-1mg
¥29400.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    IMD67, IPD1, IRAK-4, NY-REN-64, REN64

  • 表达区间及表达系统(Source)

    Human IRAK4 Protein, His Tag (IR4-H5546) is expressed from Baculovirus-Insect cells. It contains AA Met 1 - Ser 460 (Accession # Q9NWZ3-1).

    Predicted N-terminus: Met 1

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    IRAK4 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 53.4 kDa. The protein migrates as 60-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 纯度(Purity)

    >85% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Supplied as 0.2 μm filtered solution in 50 mM HEPES, 300 mM NaCl, pH7.5 with glycerol as protectant.

    Contact us for customized product form or formulation.

  • 运输(Shipping)

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • 存储(Storage)

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    IRAK4 SDS-PAGE

    Human IRAK4 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 85% (With Star Ribbon Pre-stained Protein Marker).

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背景介绍

This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.

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