Cynomolgus Integrin alpha 3 beta 1 (ITGA3&ITGB1) Heterodimer Protein, His Tag&Tag Free

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IT1-C52W6-100ug
¥4169.00
IT1-C52W6-1mg
¥28524.00
合计0件 产品金额¥ 0

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  • 分子别名(Synonym)

    Integrin alpha 3 beta 1, ITGA3&ITGB1

  • 表达区间及表达系统(Source)

    Cynomolgus ITGA3&ITGB1 Heterodimer Protein, His Tag&Tag Free (IT1-C52W6) is expressed from human 293 cells (HEK293). It contains AA Phe 30 - Glu 988 (ITGA3) & Gln 161 - Asp 868 (ITGB1) (Accession # A0A2K5VFM7 (ITGA3) & A0A7N9D0D7 (ITGB1)).

    Predicted N-terminus: Phe 30 (ITGA3) & Gln 161 (ITGB1)

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    Integrin alpha 3 beta 1 Structure

    Cynomolgus ITGA3&ITGB1 Heterodimer Protein, His Tag&Tag Free produced by co-expression of ITGA3 and ITGB1, has a calculated MW of 127.5 kDa (ITGA3) & 83.6 kDa (ITGB1). Subunit ITGA3 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus. The protein has a calculated MW of 113.1 kDa (ITGA3) & 83.6 kDa (ITGB1). The protein migrates as 110-150 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 纯度(Purity)

    >90% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    Integrin alpha 3 beta 1 SDS-PAGE

    Cynomolgus ITGA3&ITGB1 Heterodimer Protein, His Tag&Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

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背景介绍

Integrin alpha 3 beta 1 is a crucial receptor involved in various biological processes, including cell adhesion, migration, and invasion. It is composed of an alpha subunit (ITGA3) and a beta subunit (ITGB1), which together form the integrin alpha 3 beta 1 complex. This complex plays a significant role in the formation of invadopodia, which are cell membrane protrusions that facilitate cell invasion. The integrin alpha 3 beta 1 complex interacts with various extracellular matrix proteins, such as fibronectin, laminin, and collagen, and is involved in processes like matrix degradation and cell invasion. It is also implicated in the maturation of integrin beta 1, which is essential for cell survival and growth.

前沿进展

 
药物研发进展
  • 英文全称:

    Integrin alpha 3/beta 1

  • 中文全称:

    整合素α-3/β-1复合体

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    1 详情

  • 最高研发阶段:

    临床一期

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